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Effect of cytochrome P-450 inhibition and stimulation on intensity of polyethylene degradation in microsomal fraction of mouse and rat livers

✍ Scribed by M. Beranová; R. Wasserbauer; D. Vanćurová; M. Štifter; J. Očenášková; M. Mára

Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
536 KB
Volume
11
Category
Article
ISSN
0142-9612

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## Abstract Previous studies have established that chlorpyrifos (CPS), fipronil, and nonane can all be metabolized by human liver microsomes (HLM) and a number of cytochrome P450 (CYP) isoforms. However, metabolic interactions between these three substrates have not been described. In this study th