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Effect of cyclosporin on plasma lipoprotein lipase activity in rats

✍ Scribed by Jose López-Miranda; Francisco Pérez-Jiménez; Juan A. Gómez-Gerique; Antonio Espino-Montoro; Luis Hidalgo-Rojas; Javier Pedreño; Jose A. Jiménez-Perepérez

Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
576 KB
Volume
25
Category
Article
ISSN
0009-9120

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✦ Synopsis

The effects of cyclosporin on plasma lipoproteins and lipoprotein lipase (LPL) activity were studied in rats treated with different doses of the drug for periods ranging between 7 and 30 days. The treatment with cyclosporin resulted in an increase in plasma triglycerides and non-HDL-cholesterol, and a dose and time-dependent decrease of LPL activity and HDL-cholesterol, mainly because of a fall in the HDL2-cholesterol subfraction. The decrease of LPL activity was positively correlated (p < 0.01 ) with plasma HDL-cholesterol and HDL2-cholesterol and negatively with plasma triglycerides and non-HDL-cholesterol (p < 0.01).

Our results indicate that the decrease in plasma LPL activity may be responsible for the increase in plasma triglycerides and the decrease in plasma HDL-cholesterol found in rats under cyclosporin treatment.

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