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Effect of cyclosporin A on daunorubicin accumulation in multidrug-resistant P388 leukemia cells measured by real-time flow cytometry

โœ Scribed by Kees Nooter; Robert Oostrum; Richard Jonker; Herman Dekken; Willem Stokdijk; Ger Engh

Publisher
Springer
Year
1989
Tongue
English
Weight
465 KB
Volume
23
Category
Article
ISSN
0344-5704

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## Abstract Based on the fluorescence properties of adriamycin (ADM) and daunorubicin (DNR), uptake in sensitive and resistant Friend leukemia cells (FLC) was studied with the aid of the fluorescence activated cell sorter (FACS II). A quantitative cell by cell fluorescence intensity analysis showed