Effect of Cyclodextrin Charge on Complexation of Neutral and Charged Substrates: Comparison of (SBE)7M-β-CD to HP-β-CD
✍ Scribed by V. Zia; R. A. Rajewski; V. J. Stella
- Book ID
- 110296852
- Publisher
- Springer US
- Year
- 2001
- Tongue
- English
- Weight
- 147 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0724-8741
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The purpose of this study was to evaluate and compare the potential use of two parenterally safe -cyclodextrins derivatives, (SBE) 7m --CD and HP--CD, as solubilizers and stabilizers for melphalan and carmustine, two very unstable antineoplastic agents. Phase solubility and chemical stability of
NSC-281612 (4-[bis[2-[(methylsulfonyl) oxy]ethyl]amino]-2-methyl-benzaldehyde, 1), is a chemically unstable, poorly water soluble, experimental antineoplastic agent. The saturated solubility in water at 258C was determined as $30 mg/mL. In the pH range 2-11, 1 displayed pH-independent stability (t