Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice
✍ Scribed by Kwon-Il Seo; Myung-Sook Choi; Un Ju Jung; Hye-Jin Kim; Jiyoung Yeo; Seon-Min Jeon; Mi-Kyung Lee
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 612 KB
- Volume
- 52
- Category
- Article
- ISSN
- 1613-4125
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✦ Synopsis
Abstract
We investigated the effect of curcumin on insulin resistance and glucose homeostasis in male C57BL/KsJ‐db/db mice and their age‐matched lean non‐diabetic db/+ mice. Both db/+ and db/db mice were fed with or without curcumin (0.02%, wt/wt) for 6 wks. Curcumin significantly lowered blood glucose and HbA~1c~ levels, and it suppressed body weight loss in db/db mice. Curcumin improved homeostasis model assessment of insulin resistance and glucose tolerance, and elevated the plasma insulin level in db/db mice. Hepatic glucokinase activity was significantly higher in the curcumin‐supplemented db/db group than in the db/db group, whereas glucose‐6‐phosphatase and phosphoenolpyruvate carboxykinase activities were significantly lower. In db/db mice, curcumin significantly lowered the hepatic activities of fatty acid synthase, β‐oxidation, 3‐hydroxy‐3‐methylglutaryl coenzyme reductase, and acyl‐CoA: cholesterol acyltransferase. Curcumin significantly lowered plasma free fatty acid, cholesterol, and triglyceride concentrations and increased the hepatic glycogen and skeletal muscle lipoprotein lipase in db/db mice. Curcumin normalized erythrocyte and hepatic antioxidant enzyme activities (superoxide dismutase, catalase, gluthathione peroxidase) in db/db mice that resulted in a significant reduction in lipid peroxidation. However, curcumin showed no effect on the blood glucose, plasma insulin, and glucose regulating enzyme activities in db/+ mice. These results suggest that curcumin seemed to be a potential glucose‐lowering agent and antioxidant in type 2 diabetic db/db mice, but had no affect in non‐diabetic db/+ mice.