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Effect of cortical kindling on [3H]d-aspartate uptake and glutamate metabolism in rats

✍ Scribed by M.J. Leach; R.A. O'Donnell; K.J. Collins; C.M. Marden; A.A. Miller

Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
290 KB
Volume
1
Category
Article
ISSN
0920-1211

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✦ Synopsis

The effects of cortical kindling in rats on [3H]D-aspartate uptake and on glutaminase and glutamine synthetase activities has been studied. The high affinity uptake of [3H]D-aspartate in control cortical tissue (Km approximately 2 microM) was undetectable in the kindled tissue, whilst the enzyme activities were unchanged. A loss of the high-affinity uptake sites for excitatory amino acids may be a contributing factor to the kindling phenomenon.

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