Effect of Coordination on the Glucose-Responsiveness of PEG-b-(PAA-co-PAAPBA) Micelles

✍ Scribed by Beilei Wang; Rujiang Ma; Gan Liu; Xiaojun Liu; Yaohua Gao; Junyang Shen; Yingli An; Linqi Shi

• Book ID: 102495686
• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 318 KB
• Volume: 31
• Category: Article
• ISSN: 1022-1336
• DOI: 10.1002/marc.201000164

✦ Synopsis

Poly(ethylene glycol)-block-poly(acrylic acid) (PEG-PAA) is modified by 3-aminophenylboronic acid (APBA) with different modification degrees, such as PEG(114) -b-(PAA(0.37) -co-PAAPBA(0.63) )(170) , PEG(114) -b-(PAA(0.23) -co-PAAPBA(0.77) )(170) and PEG(114) -b-(PAA(0.02) -co-PAAPBA(0.98) )(170) . Micelles self-assembled from these three copolymers possess glucose-responsiveness at varying pH values. Micelles self-assembled from PEG(114) -b-(PAA(0.37) -co-PAAPBA(0.63) )(170) have glucose-responsiveness at the physiological pH (7.4), endowing them with potential applications in the treatment of diabetes. (11) B magic-angle spinning nuclear magnetic resonance ((11) B MAS NMR) analysis indicates that interactions between PAAPBA segments and PAA segments induce boron changes from the trigonal planar form to the tetrahedral form, resulting in glucose-responsiveness of PEG(114) -b-(PAA(0.37) -co-PAAPBA(0.63) )(170) micelles at pH 7.4.