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Effect of complete sulfation of bile acids on bile formation in rats

✍ Scribed by Ibrahim M. Yousef; Stephen G. Barnwell; Beatriz Tuchweber; Andrée Weber; Claude C. Roy

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
845 KB
Volume
7
Category
Article
ISSN
0270-9139

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✦ Synopsis

were prepared by using a sulfur trioxide complex (Aldrich, Milwaukee, Wis.) as described previously (Donovon, J. M. et al., Gastroenterology 1984; 84:1046, Abstract). When sulfation was complete (all the hydroxyl groups were sulfated), the purity of sulfated bile acids was better than 96% as checked by thinlayer chromatography and potentiometric titration (15a).

Male Sprague-Dawley rats weighing 200 to 250 gm (Charles River, Saint-Constant, Quehec, Canada) were maintained in an environment of constant temperature (22°C) and lighting ( 7135

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