Effect of combining BW12C with a low oxygen treatment on mouse tumor response to radiation

✍ Scribed by A. Hendrikse; G. Blekkenhorst; F. Mohamed

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 504 KB
• Volume: 4
• Category: Article
• ISSN: 1065-7541
• DOI: 10.1002/(sici)1520-6823(1996)4:6<255::aid-roi2>3.0.co;2-x

✦ Synopsis

The substituted benzaldehyde BWl2C has previously been shown to increase the sensitivity of the 3 -methylcholanthrene-induced rhabdomyosarcoma in BALB/c mice to radiation that was delivered 5 hr after administration of the drug. The radiation response of this tumor has also been shown to increase if the host animal was pretreated with 8% oxygen for 48 hr. In the present study, the radiation response of the 3-methylcholanthrene-induced rhabdomyosarcoma was investigated in BALB/c mice that were pretreated with BWl2C and then with 8% oxygen. When mice were given BWl2C and then exposed to an 8% oxygen environment for 48 hr, an increase in tumor radiosensitivity, which exceeded that resulting from BWl2C treatment alone or the low oxygen treatment alone, was observed. Results also indicated that the tumor response of mice irradiated in carbogen 5 hr after receiving BWl2C was similar to that of mice irradiated in air after being given BW12C and then a 48-hr 8% oxygen treatment.