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Effect of coenzymes on binding of steroid substrates with rat liver estrophilic hydroxysteroid dehydrogenase

✍ Scribed by A. N. Smirnov


Publisher
Springer US
Year
1990
Tongue
English
Weight
251 KB
Volume
109
Category
Article
ISSN
0007-4888

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Mouse 3(17)Ξ±-hydroxysteroid dehydrogenase (AKR1C21) is the only aldo–keto reductase that catalyzes the stereospecific reduction of 3- and 17-ketosteroids to the corresponding 3(17)Ξ±-hydroxysteroids. The Y224D mutation of AKR1C21 reduced the__K__~m~value for NADP(H) by up to 80-fold and completely re