Seven patients with bucco-lingual dyskinesia were treated with a single dose of ceruletide 0.8 gg/kg IM, a potent analogue of cholecystokinin octapeptide. Timecourse effects of the drug were then followed up to 6 weeks after injection in the longest case. To assess changes in severity of dyskinesia
Effect of co-dergocrine mesylate on tardive dyskinesia a preliminary report
โ Scribed by Jack Hajioff; Mackenzie Wallace
- Publisher
- Springer
- Year
- 1983
- Tongue
- English
- Weight
- 265 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
โฆ Synopsis
Twenty patients with signs of tardive dyskinesia secondary to antipsychotic medication participated in a double blind, controlled, parallel group study comparing codergocrine mesylate 4.5 mg once daily with a placebo. After 6 weeks medication a reduction in dyskinetic scores occurred in both groups, but at the end of a further 6-week period the patients on active treatment maintained their improvement while those on placebo did not. This may be due to a slow onset of action and a hangover of activity associated with the drug.
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The effects of three doses of interferon alpha (1.5 Mu, 0.5 Mu and 0.1 Mu) on performance were studied. The injection of 1.5 Mu IFN produced symptoms and performance changes which closely resembled those found in volunteers with influenza. Specifically, volunteers were slower at responding when they