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Effect of clarithromycin and fluconazole on the pharmacokinetics of montelukast in human volunteers

✍ Scribed by Sahar K. Hegazy, Mokhtar M. Mabrouk…

Book ID
120759248
Publisher
Springer
Year
2012
Tongue
English
Weight
370 KB
Volume
68
Category
Article
ISSN
0031-6970

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Sildenafil is the first oral therapeutic agent for the management of male erectile dysfunction. Its oral bioavailability is only 40% due to extensive presystemic elimination, mainly by CYP3A4. This study examined the effect of coadministration of ciprofloxacin or clarithromycin, which inhibit CYP3A4