Phosphopeptide Ligands of the SHP-1 N-SH
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Kornelia Hampel; Ina Kaufhold; Martin Zacharias; Frankโ
D. Bรถhmer; Diana Imhof
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Article
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2006
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John Wiley and Sons
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English
โ 424 KB
๐ 1 views
## Abstract Src homologyโ 2 (SH2)โdomainโmediated interactions with phosphotyrosine (pY)โcontaining ligands are critical for the regulation of SHPโ1 phosphatase activity. Peptides based on a binding site from receptor tyrosine kinase Ros (EGLNโpY2267โMVL, 1) have recently been shown to bind to the S