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Effect of Citrulline for Arginine Replacement on the Structure and Turnover of Phosphopeptide Substrates of Protein Phosphatase-1

โœ Scribed by Bruce L. Martin; Siquan Luo; Agustin Kintanar; Meng Chen; Donald J. Graves


Book ID
115567344
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
231 KB
Volume
359
Category
Article
ISSN
0003-9861

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## Abstract Src homologyโ€…2 (SH2)โ€domainโ€mediated interactions with phosphotyrosine (pY)โ€containing ligands are critical for the regulation of SHPโ€1 phosphatase activity. Peptides based on a binding site from receptor tyrosine kinase Ros (EGLNโ€pY2267โ€MVL, 1) have recently been shown to bind to the S