Effect of Circulating Antigen on Immunoscintigraphy of Ovarian Cancer Patients Using Anti-CA125 Monoclonal Antibody
β Scribed by Sakahara, Harumi ;Hosono, Makoto ;Kobayashi, Hisataka ;Yao, Zhengsheng ;Saga, Tsuneo ;Yano, Shinsuke ;Endo, Keigo ;Mori, Takahide ;Konishi, Junji
- Book ID
- 108581222
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1996
- Tongue
- English
- Weight
- 427 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0910-5050
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Monoclonal antibody (MAb) O C 125 binds to approximately 80% of epithelial ovarian cancers. Serum antigen, CAI25, can be detected in these patients. "'I-OC 125-F(ab')2 was injected into 5 ovarian carcinoma patients with preinjection serum levels of I50 to 9,000 CAI25 U/ml. Patients received the anti
Ovarian cancer is a highly malignant tumor of mainly postmenopausal women. The long-term prognosis of this malignancy is largely determined by micrometastasis present at the time of second-look surgery. In general, patients face a poor outcome. New radio-immunoscintigraphic methods to target tumor t