Effect of cimetidine and phenobarbital on metabolite kinetics of omeprazole in rats
β Scribed by Eun-Ja Park; Hea-Young Cho; Yong-Bok Lee
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 629 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0253-6269
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The effects of cimetidine (CIM) (an inhibitor of the hepatic microsomal monooxygenase system) on the metabolism and hepatotoxicity of trichloroethylene (TRI) were studied in male Sprague-Dawley rats. Rats were given three doses of 120 mg/kg i.p. (low-dose regimen) of CIM at 0, 6 and 11 h for 1 day,