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Effect of chronic nicotine on brain stimulation reward: I. Effect of daily injections

โœ Scribed by Michael A. Bozarth; Cindy M. Pudiak; Rhonda KuoLee


Book ID
117346327
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
84 KB
Volume
96
Category
Article
ISSN
0166-4328

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Chlorisondamine, a quarternary nicotinic antagonist, was given in a dose that crosses the blood-brain barrier, is taken up and concentrated intracellularly by dopaminergic neurons, and induces long-term blockade of the locomotor stimulant and rewarding effects of nicotine. This treatment had no effe