✦ LIBER ✦

Effect of Chronic Glutathione Deficiency on Rat Lung Mitochondrial Function

✍ Scribed by J. Thanislass; M. Raveendran; N. Sivasithamparam; H. Devaraj

Publisher: Elsevier
Year: 1996
Tongue: English
Weight: 77 KB
Volume: 9
Category: Article
ISSN: 0952-0600
DOI: 10.1006/pulp.1996.0013

No coin nor oath required. For personal study only.

✦ Synopsis

The effect of chronic glutathione deficiency on lung mitochondrial energy production using buthionine sulphoximine (BSO) as a depletor has been investigated. Prolonged depletion of mitochondrial glutathione produced an imbalance in the antioxidant defence and resulted in lipid peroxidation, which, in turn, damages the membranous structure, leading to the inactivation of inner membrane enzymes, matrix-bound enzymes and mitochondrial cytochrome content. Altered activities of energy-linked enzymes and electron transport resulted in the decreased rate of ADP-stimulated oxygen uptake, respiratory coupling ratio and ATP synthesis.

📜 SIMILAR VOLUMES

Effects of chronic emetine treatment on

Effects of chronic emetine treatment on mitochondrial function

✍ Michael A. Dubick; William C. T. Yang 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 368 KB

Effects of resveratrol analogs on steroi

Effects of resveratrol analogs on steroidogenesis and mitochondrial function in rat Leydig cells in vitro

✍ Konstantin Svechnikov; Carmela Spatafora; Irina Svechnikova; Corrado Tringali; O 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 353 KB 👁 1 views

## Abstract Resveratrol and its analogs are considered to be a promising drug candidate for treatment of cancer and different age‐associated diseases. In the present study we have investigated the effects of resveratrol and its synthetic analogs on steroidogenesis and mitochondrial function in prim

Effects of chronic growth hormone and in

Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints

✍ Kari J. Ekenstedt; William E. Sonntag; Richard F. Loeser; Bruce R. Lindgren; Cat 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 236 KB 👁 2 views

## Abstract ## Objective To determine the effects of chronic deficiency of growth hormone (GH) and insulin‐like growth factor 1 (IGF‐1) on osteoarthritis (OA) severity. ## Methods Thirty‐five rats were divided into 4 treatment groups at 4 weeks of age: 1 control group (normal GH/IGF‐1 levels [he

Effects of Nd:YAG laser irradiation on m

Effects of Nd:YAG laser irradiation on morphometry and lung function in elastase-induced emphysema in rats

✍ Akahane, Tsutomu; Kurokawa, Yoshimochi; Chiba, Ryoji; Yaegashi, Hiroshi; Takahas 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 421 KB 👁 2 views

Background & Objective: Although thoracoscopic laser ablation therapy has been hailed as an effective surgical treatment for diffuse emphysema, no one has as yet made an in-depth study of the efficacy of this treatment. This investigation was undertaken to research the effects of laser pneumoplasty

Effects of acute and chronic ethanol exp

Effects of acute and chronic ethanol exposure on spatial cognitive processing and hippocampal function in the rat

✍ Douglas B. Matthews; A. Leslie Morrow 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 309 KB 👁 2 views

Animals, including rats, have a predisposition to process and use spatial information to organize and guide behavior. The hippocampus and related structures are critically involved in this function, and, consequently, it has been proposed that one function of the hippocampus is to construct ''spatia

The pharmacokinetics of glycyrrhizin and

The pharmacokinetics of glycyrrhizin and its restorative effect on hepatic function in patients with chronic hepatitis and in chronically carbon-tetrachloride-intoxicated rats

✍ Yoshikazu Yamamura; Hajime Kotaki; Naomi Tanaka; Tatsuya Aikawa; Yasufumi Sawada 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 318 KB 👁 2 views

The relationships between the pharmacokinetic behaviour of glycyrrhizin and its restorative eect for hepatic function were investigated in patients with chronic hepatitis and in rats chronically treated with carbon tetrachloride (CCl 4 -treated rats). In patients, the restorative eects in plasma asp