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Effect of chlorpromazine on glucose and tolbutamide-stimulated insulin release in the adrenalectomized rat

✍ Scribed by Allan S. Susten; John H. Mennear; Tom S. Miya


Book ID
119001677
Publisher
Elsevier Science
Year
1973
Tongue
English
Weight
489 KB
Volume
24
Category
Article
ISSN
0041-008X

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The permissive effect of glucose, tolbut
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Mouse islets were used to study how glucose modulates arginine stimulation of insulin release. At 3 mmol/l glucose, arginine (20 mmol/l) decreased the resting membrane potential of B cells by about 10 mV, but did not evoke electrical activity. This depolarisation was accompanied by a slight but rapi