𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of chloroquine on the PHA-induced lymphocyte transformation

✍ Scribed by Thomas Ruzicka; Herbert Loosen; Dirk Straßburger; Günter Goerz

Publisher
Springer-Verlag
Year
1980
Tongue
English
Weight
162 KB
Volume
267
Category
Article
ISSN
0340-3696

No coin nor oath required. For personal study only.

✦ Synopsis

Moorenstr. 5, Federal Republic of Germany

Chloroquine (C) is therapeutically used in lupus erythematosus and other immunologic and non-immunologic diseases. Numerous contributions on its mode of action appeared in the literature [8,9,15], but the basis for its effectiveness is not yet clear. The lymphocyte transformation by mitogens became one of the standard methods in the evaluation of cell-mediated immunity [13]. We investigated the action of chloroquine in this in vitro system.

📜 SIMILAR VOLUMES

Effect of TGF-β1 on the ebv-induced tran
Effect of TGF-β1 on the ebv-induced transformation of human lymphocyte cultures
✍ Aysin Altiok; Maria Teresa Bejarano; George Klein; Eva Klein 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 554 KB

We tested the effect of TGF-PI on the EBV-induced activation and immortalization of human B lymphocytes. In Iymphocyte cultures of EBV-seropositive individuals, T cells can inhibit the EBV-induced transformation of B cells. We found that in the presence of TGF-f3 I the transformation was more effici