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Effect of chloroquine on proteolytic processes and energy metabolism in yeast

✍ Scribed by Anke-Gabriele Lenz; Helmut Holzer

Publisher
Springer
Year
1984
Tongue
English
Weight
731 KB
Volume
137
Category
Article
ISSN
0302-8933

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✦ Synopsis

In yeast cells, degradation of cellular proteins was inhibited by addition of chloroquine to the medium as shown by a decrease of the release of trichloroacetic acid-soluble radioactivity from prelabelled cell protein. Penetration of chloroquine into the cells was strongly enhanced with increasing pH value of the medium. The concentration in the cells reached 5 -1 4 times that in the medium of pH 8.0. Fluorescence microscopy showed that chloroquine was concentrated in the vacuoles of the cells. Chloroquine, at concentrations attained in the cells, inhibited the activities of vacuolar proteinases in vitro. Furthermore, chloroquine caused a rapid and drastic decrease of the ATP dontent of the cells and prevented the fermentation of glucose and formation of ethanol under aerobic conditions.

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