Effect of ligand binding on the intramin
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Burak Alakent; Sena Baskan; Pemra Doruker
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Article
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2010
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John Wiley and Sons
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English
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## Abstract Effects of ligand binding on protein dynamics are studied via molecular dynamics (MD) simulations on two different enzymes, dihydrofolate reductase (DHFR) and triosephosphate isomerase (TIM), in their unliganded (free) and liganded states. Domain motions in MD trajectories are analyzed