Effect of certain tetracycline analogs on phenylalanine-14C incorporation by Escberichia coli B cell-free extracts
✍ Scribed by Carl B. Rifino; William F. Bousquet; Adelbert M. Knevel; Patrick Belcastro; Alfred N. Martin
- Publisher
- John Wiley and Sons
- Year
- 1968
- Tongue
- English
- Weight
- 258 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
I1
in relation to the caffeine molecule. This arrangement is consistent with the ideas presented above for polarization bonding. A more detailed account of this material will be published at a later date.
In conclusion, it is felt that in order to propose molecular models for xanthine complexes of pharmaceutical interest, one should take into account polarization interactions. Studies on other pyrimidine and purine complexes are being carried out in this laboratory to shed more light on this problem.
Effect of Certain Tetracycline Analogs on Phenylalanine-1 4 C Incorporation by Escherichiu coli B Cell-free Extracts
Sir:
This communication reports the effects of several tetracycline analogs on messenger RNA (mRNA) and polyuridylic acid (poly U)-directed phenylalanine-14C incorporation by E. coli B cellfree extracts. This study was undertaken to determine (u) if mRNA and poly U-directed amino acid incorporation are differentially sensitive to inhibition by the tetracyclines, and (6) to examine structure-activity relationships in this series of drugs.
The tetracyclines have been observed (1) to (IYtiSj.