Effect of certain nonionic surfactants on the absorption of salicylic acid from solutions by the frog, Rana pipiens

✍ Scribed by Clyde W. Whitworth; Earl R. Carter

• Publisher: John Wiley and Sons
• Year: 1969
• Tongue: English
• Weight: 364 KB
• Volume: 58
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600581033

✦ Synopsis

Three concentrations each of polysorbate 20, polysorbate 40, polysorbate 60, and polysorbate 80 were added to dilute buffered solutions of salicylic acid and absorption of the drug by the frog studied by an immersion technique. The more dilute concentrations of polysorbate 20 and polysorbate 40 were almost as effective in increasing absorption as were the higher concentrations of polysorbate 60 and polysorbate 80. The absorption process appears to be first-order, based on the concentration of drug remaining in solution. Statistical comparisons were made. Surface tensions of solutions were determined and dialysis methods were used to detect complexation. The surfactants used definitely influenced absorption. The effect appears to be due to complexation and possibly surface tension lowering.

Keyphrases 0 Salicylic acid absorption-polysorbates 20, 40, concentration on absorption. Present research is proceeding along these lines.

(6) G. Levy and J. A. Anello, ibid., 57, lOl(1968).