Effect of certain drugs on perfused human placenta X: Norepinephrine release by bradykinin

✍ Scribed by William T. Sherman; Ronald F. Gautieri

• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: English
• Weight: 723 KB
• Volume: 61
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600610610

✦ Synopsis

Norepinephrine was detectable chemically in the placental perfusate in two separate instances: ( a ) endogenously, when the initial control pressor response to bradykinin was observed to be significantly higher than those following, and (b) during the bradykinin response that followed the administration of exogenous norepinephrine. Additionally, the pressor response observed with bradykinin was augmented by the prior administration of norepinephrine. Tritium-labeled norepinephrine was administered to the placenta in an attempt to understand better the type of storage taking place, but characterization of the uptake was not possible. The pressor response that bradykinin exerted upon the placenta was not diminished by the preadministration of the parasympatholytic, atropine, or the antiserotonin and antihistaminic drug, diphenhydramine. Administration of a-adrenergic blocking agents to the placenta did, on occasion, reduce the pressor response to bradykinin. However, the evaluation suggests that there is no statistical difference between the pressor response to bradykinin before the administration of phenoxybenzamine, tolazoline, or phentolamine and those responses to bradykinin after their administration.

Keyphrases 0 Placenta perfusates-norepinephrine release by bradykinin 0 Norepinephrine-release by bradykinin in perfused human placenta 0 Bradykinin-pressor-induced release of norepinephrine in perfused human placenta