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Effect of certain drugs on perfused human placenta ix: Mode of action of angiotensin

โœ Scribed by Charles O. Ward; Ronald F. Gautieri

Publisher
John Wiley and Sons
Year
1969
Tongue
English
Weight
397 KB
Volume
58
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

By the use of compounds that directly depress vascular smooth muscle, block a-adrenergic receptors, or block 8-adrenergic receptors, it was shown that a triple mechanism is involved in the pressor action of angiotensin in isolated, perfused human placental blood vessels. Angiotensin directly stimulates vascular smooth muscle and a-adrenergic receptors while concomitantly stimulating p-adrenergic receptors, to offset the effect of the first two mechanisms. Thus, when the 8-receptors are blocked, the pressor response to angiotensin is augmented. Key phrases 0

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