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Effect of casopitant, a novel NK-1 antagonist, on the pharmacokinetics of dolasetron and granisetron

✍ Scribed by Laurel M. Adams; Brendan Johnson; Ke Zhang; Lin Yue; Lyndon C. Kirby; Peter Lebowitz; Randall Stoltz


Publisher
Springer-Verlag
Year
2009
Tongue
English
Weight
161 KB
Volume
17
Category
Article
ISSN
0941-4355

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Utilizing a human NK 1 receptor antagonist (RPR 100893), the present in vivo study was designed to test the hypothesis that endogenous substance P (SP) modulates the action of 17␀-estradiol in inducing luteinizing hormone (LH) and follicle stimulating hormone (FSH) surges in ovariectomized cynomolgu