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Effect of calcitonin on the phosphorylation of non-histones from cultured bone cells

✍ Scribed by Sergio E. Bustos; George S. Schuster; Thomas R. Dirksen; Ralph V. McKinney; David Y.-L. Lai

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
389 KB
Volume
92
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

^32^P‐uptake into non‐histones from bone cell cultures was selectively stimulated in the presence of calcitonin. Comparison of the control and experimental radioactivity profiles of non‐histones fractionated by SDS gel electrophoresis showed that, in response to calcitonin stimulation, there was a 2‐ to 3‐fold increase in the specific activity associated with non‐histone proteins in the molecular weight range of 10,000 to 45,000 daltons while that of bands between 50,000 to 200,000 decreased.

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