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Effect of butylated hydroxyanisole on the toxicity of 2-hydroxy-1,4-naphthoquinone to rats

โœ Scribed by Rex Munday; Barry L. Smith; Christine M. Munday

Book ID
114009675
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
148 KB
Volume
117
Category
Article
ISSN
0009-2797

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Mechanisms of toxicity of 2- and 5-hydroxy-1,4-naphthoquinone; absence of a role for redox cycling in the toxicity of 2-hydroxy-1,4-naphthoquinone to isolated hepatocytes
โœ Mary D'Arcy Doherty; Adrian Rodgers; Gerald M. Cohen ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 569 KB

The mechanisms of toxicity to isolated rat hepatocytes of two structurally related naphthoquinones have been studied. Both 5-OH-1,4-naphthoquinone (5-OH-1,4-NQ; juglone) and 2-OH-1,4-naphthoquinone (2-OH-1,4-NQ; lawsone) caused a concentration-dependent cytotoxicity to hepatocytes which was preceded