Effect of Buthionine Sulphoximine, Glutathione and Methimazole on the Renal Disposition of Cisplatin and on Cisplatin-induced Nephrotoxicity in Rats: Pharmacokinetic-Toxicodynamic Analysis
โ Scribed by KAZUHIKO HANADA; YUJI MUKASA; YUKO NOMIZO; HIROYASU OGATA
- Book ID
- 111768596
- Publisher
- Pharmaceutical Press
- Year
- 2000
- Tongue
- English
- Weight
- 104 KB
- Volume
- 52
- Category
- Article
- ISSN
- 2042-7158
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The anticancer drug cisplatin has been known to produce severe renal lesions characterized by high levels of blood urea nitrogen (BUN), toxic nephrosis, and platinum (Pt) retention in the kidney. The effect of IV pretreatment with acetazolamide (ACZ) 30 min before or mannitol (MAN) immediately prior
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