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Effect of busulphan treatment and elevated temperature on the expression of the β-pol gene in rat testis

✍ Scribed by Radoslawa Nowak; Janusz A. Siedlecki

Publisher
Springer
Year
1991
Tongue
English
Weight
579 KB
Volume
15
Category
Article
ISSN
0301-4851

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✦ Synopsis

Changes in the expression pattern of the DNA polymerase fl gene during inhibition of spermatogenesis by busulphan and by temperature (artificial cryptorchidism) have been studied. Transient arrest of spermatogenesis in two-month-old rats after injection of a single dose of busulphan (10 mg/kg) resulted in parallel but transient decrease in the 1.4 kb of fl-pol mRNA level to an undetectable value, followed by its reappearance after resumption of spermatogenesis. An artificial cryptorchidism also caused a drastic decrease of fl-pol mRNA level. Both results as well as morphological examination of testis after busulphan injection and artificial cryptochidism revealed that spermatocytes and spermatids represent the testicular cell fraction containing the elevated amount of fl-pol mRNA. Involvement of DNA polymerase fl in meiotic recombination is discussed.

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