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Effect of buspirone on rat plasma prolactin levels and striatal dopamine turnover

โœ Scribed by H. Y. Meltzer; M. Simonovic; V. S. Fang; G. A. Gudelsky

Publisher
Springer
Year
1982
Tongue
English
Weight
520 KB
Volume
78
Category
Article
ISSN
0033-3158

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โœฆ Synopsis

Buspirone, an effective antianxiety compound, produced a dose-dependent, relatively prolonged increase in rat plasma prolactin (PRL) levels. The stimulation of PRL secretion by buspirone was additive with the effect of e-methyl-p-tyrosine (AMPT) or y-butyrolactone. In vitro, buspirone itself had no effect on the release of PRL from rat pituitary glands but it blocked the inhibitory action of dopamine (DA). Buspirone also increased DA turnover in the striatum as measured by the AMPT-induced depletion of striatal DA levels. These results demonstrate the ability of buspirone to block pituitary and striatal DA receptors.

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