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Effect of buffer constituents and time on drug transfer across in vitro rat intestine

โœ Scribed by Leslie Z. Benet; James M. Orr; Robert H. Turner; Howard S. Webb


Publisher
John Wiley and Sons
Year
1971
Tongue
English
Weight
559 KB
Volume
60
Category
Article
ISSN
0022-3549

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Drug transport III: Influence of various
โœ Michael Mayersohn; Milo Gibaldi ๐Ÿ“‚ Article ๐Ÿ“… 1971 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 763 KB

Depending upon the sugar (monosaccharide) present in the drug-buffer solution (isotonic Krebs bicarbonate, pH 7.4), one can effectively alter the passive transfer of several drugs across the everted rat intestine. A similar phenomenon was noted in a previous study concerned with the influence of var