Effect of branched-chain amino acids on glutamate metabolism in amyotrophic lateral sclerosis
✍ Scribed by Ole Gredal; Svend Erik Møller
- Book ID
- 118931881
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 361 KB
- Volume
- 129
- Category
- Article
- ISSN
- 0022-510X
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Recently, the excitatory amino acid neurotransmitter glutamate was implicated in the pathogenesis of a variety of chronic degenerative neurological diseases in humans and animals. This report describes abnormalities in excitatory amino acids in the central nervous system of 18 patients with amyotrop
## Abstract **Scope:** We hypothesized that chronic supplementation with branched chain amino acids (BCAAs) affects neurobehavioral development in vulnerable gene backgrounds. **Methods and results:** A murine model of amyotrophic lateral sclerosis (ALS), G93A mice bearing the mutated human supero