Effect of body weight on the pharmacokinetics of cyclophosphamide in breast cancer patients
โ Scribed by Garth Powis; Phillip Reece; David L. Ahmann; James N. Ingle
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 427 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0344-5704
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๐ SIMILAR VOLUMES
## Abstract Stimulation of tumor growth and induced hypercalcemia both may occur during the initiation of estrogen therapy in breast cancer. This study was conducted to determine whether cyclophosphamide (CTX) as an adjuvant to estrogen therapy might (1) prevent induced hypercalcemia or (2) achieve
We investigated the immunomodulatory effect of cyclophosphamide on the induction of suppressor cell activities in peripheral blood lymphocytes. The sera from advanced breast cancer patients as well as concanavalin-A (Con-A) induced suppressor cell activities in lymphocytes from healthy volunteers. P
The complete pharmacokinetics (PK) of (R)-and (S)-cyclophosphamide (CP) and their dechloroethylated (DCE) metabolites have not been reported to date. We collected plasma and urine samples from 12 cancer patients and determined concentrations of both enantiomers of CP and DCE-CP using a chiral GC-MS