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Effect of blood collection tubes on antidepressant concentrations

✍ Scribed by J.S. Kennedy; H. Friedman; J.M. Scavone; J.S. Harmatz; R.I. Shader; D.J. Greenblatt

Publisher
Elsevier Science
Year
1987
Weight
172 KB
Volume
423
Category
Article
ISSN
0378-4347

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## Abstract Levodopa combined with a dopa‐decarboxylase inhibitor, such as carbidopa, shifts the metabolism to the COMT pathway. Adding the peripheral acting COMT inhibitor entacapone provides improvement for patients with PD suffering from motor fluctuations. We studied the effects of the enzyme i