Effect of biological toxins on gap-junctionai intercellular communication in Chinese hamster V79 cells

✍ Scribed by Cyrenius Jone; Laurie Erickson; James E. Trosko; Chia C. Chang

• Book ID: 104627618
• Publisher: Springer
• Year: 1987
• Tongue: English
• Weight: 855 KB
• Volume: 3
• Category: Article
• ISSN: 0742-2091
• DOI: 10.1007/bf00117821

✦ Synopsis

Since chemical modulation of gap-junctional intercellular communication has been implicated in several toxicological endpoints, a study to examine the ability of several biological toxins to inhibit this process was undertaken. Eight biological toxins were tested for their ability to inhibit metabolic cooperation, a measure of gap-junctional intercellular communication, in the Chinese V79 cell system. Aplysiatoxin, anhydrodebromoaplysiatoxin and debromoaplysiatoxin showed the strongest ability to inhibit metabolic cooperation while T2-toxin and vomitoxin inhibited metabolic cooperation to a lesser degree. Aflatoxin B1, aflatoxin B2 and palytoxin were inactive in the Chinese V79 system. Palytoxin, which was extremely cytotoxic, might act as a tumor promoter if it induces compensatory hyperplasia in vivo.