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Effect of bioflavonoids on vincristine transport across blood–brain barrier

✍ Scribed by Yoshiharu Mitsunaga; Hitomi Takanaga; Hirotami Matsuo; Mikihiko Naito; Takashi Tsuruo; Hisakazu Ohtani; Yasufumi Sawada


Book ID
114012954
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
414 KB
Volume
395
Category
Article
ISSN
0014-2999

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## Abstract In adult rats, using the single‐pass brain uptake technique with a tritiated water standard, L‐phenylalanine was shown to enter brain across the blood‐brain barrier (BBB) by both a saturable and diffusionary process. A kinetic analysis of the data revealed Michaelis constant (K~a~) of 0