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Effect of binders on the release rates of direct molded verapamil tablets using twin-screw extruder in melt granulation

โœ Scribed by Tan, David Cheng Thiam; Chin, William Wei Lim; Tan, En Hui; Hong, Shiqi; Gu, Wei; Gokhale, Rajeev

Book ID
123262280
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
868 KB
Volume
463
Category
Article
ISSN
0378-5173

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Application of melt granulation technolo
Application of melt granulation technology using twin-screw extruder in development of high-dose modified-release tablet formulation
โœ Madhav Vasanthavada; Yanfeng Wang; Thomas Haefele; Jay P. Lakshman; Manisha Mone ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 414 KB

Development of modified-release oral tablets of drug products usually requires release-modifying polymers at the level of above 50% of the total weight. This makes the development of high-dose products, especially with doses in the range of 750-1000 mg, difficult because the tablet size becomes unac