## 4BSTRACT The results of this investigation indicate that with a progressive increase in the initial bile salt concentration within the mucosal and serosal compartments of everted sacs of rat and hamster ileum, a decrease i n tissue ATP levels is observed.
Effect of bile and lipids on the stereoselective metabolism of halofantrine by rat everted-intestinal sacs
โ Scribed by Jigar P. Patel; Hesham M. Korashy; Ayman O.S. El-Kadi; Dion R. Brocks
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 156 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0899-0042
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The effect of hyperlipidemia on the biodistribution of (+/-)-halofantrine (HF) was studied in rats. Plasma, adipose, and highly perfused tissues heart, lung, liver, kidney, spleen and brain were harvested for up to 48 h after dosing animals with 2 mg/kg (+/-)-HF intravenously by tail vein. Stereospe
The objective of this study was to determine the effect of lipids on the pharmacokinetics of halofantrine enantiomers. Rats were given (+/-)-halofantrine HCl 2 mg/kg i.v., or 7 mg/kg orally. Some rats were rendered hyperlipidemic by intraperitoneal administration of poloxamer 407 1 g/kg, followed by