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Effect of bile and lipids on the stereoselective metabolism of halofantrine by rat everted-intestinal sacs

โœ Scribed by Jigar P. Patel; Hesham M. Korashy; Ayman O.S. El-Kadi; Dion R. Brocks


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
156 KB
Volume
22
Category
Article
ISSN
0899-0042

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The effect of hyperlipidemia on the biodistribution of (+/-)-halofantrine (HF) was studied in rats. Plasma, adipose, and highly perfused tissues heart, lung, liver, kidney, spleen and brain were harvested for up to 48 h after dosing animals with 2 mg/kg (+/-)-HF intravenously by tail vein. Stereospe

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The objective of this study was to determine the effect of lipids on the pharmacokinetics of halofantrine enantiomers. Rats were given (+/-)-halofantrine HCl 2 mg/kg i.v., or 7 mg/kg orally. Some rats were rendered hyperlipidemic by intraperitoneal administration of poloxamer 407 1 g/kg, followed by