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Effect of benzyl succinate on insulin receptor function and insulin action in skeletal muscle: Further evidence for a lack of spare high-affinity insulin receptors

✍ Scribed by Gumà, A.; Viñals, F.; Camps, M.; Lizarbe, M.; Mora, C.; Bertran, J.; Testar, X.; Palacín, M.; Zorzano, A.

Book ID: 123448520
Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 653 KB
Volume: 91
Category: Article
ISSN: 0303-7207
DOI: 10.1016/0303-7207(93)90251-E

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We investigated the effect of phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator on insulin receptors and insulin action in freshly isolated and primary cultures of rat hepatocytes. PMA (1 x 10(-7) M) did not alter insulin receptor numbers or affinity either acutely or chronic