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Effect of bcl-2 overexpression in mice on ovotoxicity caused by 4-vinylcyclohexene

✍ Scribed by Jodi A. Flaws; Samuel L. Marion; Kimberly P. Miller; Patricia J. Christian; Janice K. Babus; Patricia B. Hoyer

Book ID
113923890
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
416 KB
Volume
215
Category
Article
ISSN
0041-008X

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Previous studies on cell cycle regulation in the ocular lens using transgenic mice have shown that inactivation of the retinoblastoma tumor suppressor protein (pRb) can cause postmitotic lens fiber cells to enter the cell cycle. However, when the p53 gene and protein are intact, inactivation of pRb