Effect of basic and acidic additives on the (S)-proline and Pd mediated kinetic resolution of 3,5,5-trimethyl cyclohexanone and asymmetric hydrogenation of isophorone

Enantioselective hydrogenation of isopho

Enantioselective hydrogenation of isophorone and kinetic resolution of 3,3,5-trimethylcyclohexanone over Pd catalysts in the presence of (S)-proline

✍ Shuang Li; Ensheng Zhan; Yong Li; Yide Xu; Wenjie Shen 📂 Article 📅 2008 🏛 Elsevier Science 🌐 English ⚖ 570 KB

Enantioselective hydrogenation of isophorone and kinetic resolution of 3,3,5-trimethylcyclohexanone (TMCH) over Pd catalysts in the presence of (S)-proline revealed that the enantioselectivity for hydrogenation of isophorone was mainly originated from the kinetic resolution of TMCH. The rapid hydrog