𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of base concentration on the rate of the vicarious nucleophilic substitution of hydrogen and on the kinetic isotope effect

✍ Scribed by Mieczyslaw Ma̢kosza; Tadeusz Lemek; Andrzej Kwast

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
211 KB
Volume
40
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Varying concentration of the chloromethyl tolyl sulfone carbanion influences the rate of its VNS reaction with 2-fluoro-4-bromonitrobenzene and changes the mechanistic scheme from thermodynamic to kinetic control. Both primary and secondary kinetic isotope effects are observed and are clearly connected with particular kinetic relations.

📜 SIMILAR VOLUMES

The Effect of Solvent Variation on Nucle
The Effect of Solvent Variation on Nucleophilic Substitution Rates of Methyl Tosylate
✍ Paul Müller; Bernard Siegfried 📂 Article 📅 1972 🏛 John Wiley and Sons 🌐 German ⚖ 435 KB

## Abstract Rates of the reactions between bromide ion and methyl tosylate have been determined in 12 solvents and extrapolated to infinite dilution. The data are correlated with __Parker__'s solvent activity coefficients by means of an empirical equation of the type: logk^s^ – logk^0^ = A log^0^γ