Effect of axillary nodal status on the long-term survival following mastectomy for breast carcinoma: Nodal metastases may not always suggest systemic disease
✍ Scribed by Dr. Jung Hyun Yang; Nelson H. Slack; Dr. Takuma Nemoto
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 431 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0022-4790
No coin nor oath required. For personal study only.
✦ Synopsis
Records of 215 patients receiving radical mastectomies from 1958 to 1968 at Roswell Park Memorial Institute were reviewed for the significance of axillary nodal status on long-term survival and recurrence. Ten-year disease-free interval rates were 83 % , 47%, and 17%, respectively, for patients with negative nodes, 1-3 positive nodes, and > 4 positive nodes.
Fifteen-year rates were 80%, 37 % , and 8 % , respectively. Survival and disease-free interval curves for the 3 nodal status groups were significantly different from each other (P 13) were similar in overall survival, but were significantly (P =0.04) different for disease-free interval, due to a rapid rate of recurrence in the 2 13 positive node group.
Hazard rates of treatment failure during each successive 3-year period for 9 years following mastectomy for those with 1-3 positive nodes or > 4 positive nodes decreased with time, whereas the rates for those with negative nodes were low and relatively constant throughout follow-up. These findings support the thesis that a significant proportion of negative nodes patients are cured by mastectomy and that a smaller group of nodepositive patients have regional disease with a chance of cure by mastectomy.