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Effect of atropine, propranolol, and atenolol on wave structure of heart rate oscillations in rats

✍ Scribed by O. V. Sergeeva; N. N. Alipov; V. M. Smirnov

Publisher
Springer US
Year
2008
Tongue
English
Weight
203 KB
Volume
145
Category
Article
ISSN
0007-4888

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Effect of altered AGP plasma binding on
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✍ T.J. van Steeg; E.H.J. Krekels; J. Freijer; M. Danhof; E.C.M. de Lange πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 203 KB

In contrast to the impact of plasma protein binding on pharmacokinetics, no quantitative in vivo information is available on its impact on pharmacodynamics. The pharmacokinetic-pharmacodynamic relationship of the model drug S(Γ€)-propranolol was evaluated using mechanism-based estimations of in vivo