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Effect of aromatic acids on the influx of aromatic amino acids in rat brain slices

✍ Scribed by P. Lähdesmäki; M. -L. Hannus

Publisher
Springer-Verlag
Year
1977
Tongue
English
Weight
596 KB
Volume
30
Category
Article
ISSN
0014-4819

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✦ Synopsis

The influx of [3H]phenylalanine, [3H]tyrosine and [3H]tryptophan into brain cells was studied using brain slices from adult rats. Each aromatic amino acid inhibited the influx of the others into the brain cells. Tryptophan inhibited non-competitively the influx of phenylalanine, and phenylalanine similarly that of tyrosine and tryptophan. On the other hand, tyrosine inhibited competitively the influx of phenylalanine, and similarly tryptophan that of tyrosine, and tyrosine that of tryptophan. Among the aromatic organic acids tested, only phenylpyruvate and homogentisate had any inhibitory effect on the influx of the aromatic amino acids. These effects were generally competitive, non-competitive inhibition being obtained only in the inhibition of phenylalanine influx by homogentisate. The existence of only one common transport system for aromatic amino acids appear to be unlikely.

📜 SIMILAR VOLUMES

Effect of aromatic acids on protein synt
Effect of aromatic acids on protein synthesis in subcellular preparations from the rat brain
✍ Lähdesmäki, P. ;Oja, S. S. 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 English ⚖ 497 KB

## Abstract The incorporation of [^3^H]phenylalanine, [^3^H]tyrosine, and [^3^H]tryptophan into protein and amino acyl–tRNA was studied in cell‐free preparations from rat brain. Tyrosine and tryptophan inhibited the incorporation of phenylalanine into protein, and tyrosine inhibited the incorporati