𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of antiretroviral agents on carbohydrate metabolism in HIV-1 infected pregnant women

✍ Scribed by Patrícia El Beitune; Geraldo Duarte; Milton César Foss; Renan Magalhães Montenegro Jr; Patricia Spara; Silvana Maria Quintana; Ernesto Antonio Figueiró-Filho; Antonio Gadelha da Costa; Francisco Mauad Filho

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
85 KB
Volume
22
Category
Article
ISSN
1520-7552

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

Despite the correlation between the use of protease inhibitors (PI) and adverse metabolic glycemic events, no prospective study has examined these parameters in pregnant women who use these drugs.

Methods

A prospective study was conducted on 57 pregnant women to investigate the effect of antiretroviral drugs (ARV) on the carbohydrate metabolism during pregnancy. The women were divided into three groups: ZDV Group, 20 HIV‐1 infected women taking ZDV; TT Group, 25 patients on triple antiretroviral treatment (ZDV + 3TC + NFV); and Control Group, 12 pregnant women. Blood samples were obtained during the first visit for the determination of fasting plasma glycemia, when the patients were also submitted to a 75 g oral glucose test (OGTT‐75g). These procedures were performed four times along pregnancy.

Results

The median values of the area under the glycemia curve (AUC) determined over a period of 120 min between the 33rd and 38th week were 11 685 mg/dL for the Control Group, 13 477 mg/dL for the ZDV Group, and 13 650 mg/dL for the TT Group (p = 0.049). There was an increase in the AUC along pregnancy for all three groups studied, regardless of the treatment used, although this increase was significant only in the TT Group (p = 0.001). The antiretroviral agents had no deleterious effects on prematurity, low birth weight, intrauterine growth restriction rates, or on Apgar score.

Conclusion

An association was detected between the use of PI and the development of carbohydrate intolerance during pregnancy. The antiretroviral agents had no deleterious effects on perinatal prognosis. Copyright © 2005 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

An instrumental variables evaluation of
An instrumental variables evaluation of the effect of antidepressant use on employment among HIV-infected women using antiretroviral therapy in the United States: 1996–2004
✍ Omar Galárraga; David S. Salkever; Judith A. Cook; Stephen J. Gange 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 244 KB 👁 1 views

## Abstract Depression is a common condition among patients with HIV. This paper uses panel data for 1234 participants from the Women's Interagency HIV Study to estimate the effect of antidepressant use on the likelihood of being employed among women receiving highly active antiretroviral therapy (

Effect of the HIV-1 syncytium-inducing p
Effect of the HIV-1 syncytium-inducing phenotype on disease stage in vertically-infected children
✍ Fitzgibbon, Joseph E.; Gaur, Sunanda; Gavai, Medha; Gregory, Patrice; Frenkel, L 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 101 KB 👁 2 views

The syncytium-inducing (SI) capability of HIV-1 isolates from 48 HIV-infected children was determined in order to examine the association of the SI phenotype with an AIDS diagnosis and/or with other clinical parameters in HIV-infected children. In a retrospective cross-sectional analysis, phenotypic

Double-edged effect of Vγ9/Vδ2 T lymphoc
Double-edged effect of Vγ9/Vδ2 T lymphocytes on viral expression in an in vitro model of HIV-1/mycobacteria co-infection
✍ Priscilla Biswas; Marina Ferrarini; Barbara Mantelli; Claudio Fortis; Guido Poli 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 384 KB

A reciprocal influence exists between mycobacteria and HIV: HIV-infected individuals are more susceptible to mycobacterial infections and, on the other hand, mycobacterial infection results inacceleration of HIV disease progression. Vgamma9/Vdelta2 T lymphocytes are known to participate in the defen

The effect of allogeneic in vitro stimul
The effect of allogeneic in vitro stimulation and in vivo immunization on memory CD4+ T-cell APOBEC3G expression and HIV-1 infectivity
✍ Pido-Lopez Jeffrey; Yufei Wang; Thomas Seidl; Kaboutar Babaahmady; Robert Vaugha 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 372 KB 👁 1 views

## Abstract Allogeneic immunity is one of the most potent natural immune responses. APOBEC3G (A3G) is an intracellular anti‐viral factor that deaminates cytidine to uridine. Allogeneic stimulation of human CD4^+^ T cells __in vitro__ upregulated A3G mRNA and a significant correlation was found betw