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Effect of anticancer agents neothramycin, aclacinomycin, FK-565 and FK-156 on the release of interleukin-2 and interleukin-1 in vitro

✍ Scribed by Khalid Ahmed; John L. Turk

Publisher
Springer-Verlag
Year
1989
Tongue
English
Weight
585 KB
Volume
28
Category
Article
ISSN
0340-7004

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✦ Synopsis

Four anticancer agents, neothramycin, aclacinomycin, FK-565 and FK-156, were tested for their effects on concanavalin-A-induced interleukin-2 release from rat splenocytes in vitro. Neothramycin showed an enhancement of the release of interleukin-2, whereas aclacinomycin had no effect. FK-565 and FK-156 were found to inhibit the release of interleukin-2 under similar conditions. The inhibition was much more marked with FK-565. These drugs were also tested for their effects on the release of interleukin-1 from rat peritoneal exudate cells stimulated by lipopolysaccharide in vitro. Neothramycin and aclacinomycin did not affect the release of interleukin-1 ; however, both FK-565 and FK-156 resulted in its enhanced release under these conditions.

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