Effect of antibiotics on the properties of poly(methylmethacrylate)-based bone cement

✍ Scribed by He, Y. ;Trotignon, J. P. ;Loty, B. ;Tcharkhtchi, A. ;Verdu, J.

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 418 KB
• Volume: 63
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/jbm.10405

✦ Synopsis

Abstract

The goal of this study was to examine the relationship between gentamicin concentration in Palacos R bone cement (in the mass fraction range of 0–9.4%) and various properties of the cement. The results from the thermal, density, and static compression tests show that gentamicin favors the cement polymerization in its final steps, and forms a diphasic structure with the cement [poly(methylmethacrylate)] matrix. The static compression properties in the dry state are only slightly modified by the presence of the antibiotic. Concerning aging in water at 37 °C, two types of behavior can be distinguished: below a critical concentration, approximately 3–4%, the extraction of gentamicin by water is slow and there is only a slight change of static compression properties. In contrast, above this critical concentration, the gentamicin extraction is fast and almost complete after 48 weeks, and there is a considerable loss of static compression properties. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res (Appl Biomater) 63: 800–806, 2002