𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of anesthetic structure on inhalation anesthesia: Implications for the mechanism

✍ Scribed by Michael H. Abraham; William E. Acree Jr; Christina Mintz; Stacy Payne

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
186 KB
Volume
97
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

✦ Synopsis

Many previous attempts (e.g., the Meyer-Overton hypothesis) to provide a single set of physical or chemical characteristics that accurately predict anesthetic potency have failed. A finding of a general predictive correlation would support the notion of a unitary theory of narcosis. Using the Abraham solvation parameter model, the minimum alveolar concentration, MAC, of 148 varied anesthetic agents can be fitted to a linear equation in log (1/MAC) with R(2) = 0.985 and a standard deviation, SD = 0.192 log units. Division of the 148 compounds into a training set and a test set shows that log (1/MAC) values can be predicted with no bias and with SD = 0.20 log units. The two main factors that determine MAC values are compound size and compound hydrogen bond acidity, both of which increase anesthetic activity. Shape has little or no effect on anesthetic activity. Our observations support a unitary theory of narcosis by inhalation anesthetics. A two-stage mechanism for inhalation anesthesia accounts for the observed structural effects of anesthetics. In this mechanism, the first main step is transfer of the anesthetic to the site of action, and the second step is interaction of the anesthetic with a receptor(s).

📜 SIMILAR VOLUMES

Comparison of the effects of inhalation,
Comparison of the effects of inhalation, epidural, spinal, and combined anesthesia techniques on rat cremaster muscle flap microcirculation
✍ Mehmet Bozkurt; Yalcin Kulahci; Fatih Zor; Huseyin Sen; Cengiz Han Acikel; Musta 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 230 KB

## Abstract ## Background: This experimental study was designed to investigate and compare the effects of different anesthesia techniques on rat cremaster muscle flap microcirculation. ## Methods: Fifty male Sprague‐Dawley rats (130–150 g body weight) were divided into five experimental groups c

Effect of the Brush Structure on the Deg
Effect of the Brush Structure on the Degradation Mechanism of Polystyrene–Clay Nanocomposites
✍ Kai Chen; Michael A. Susner; Sergey Vyazovkin 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 167 KB

## Abstract **Summary:** Pyrolysis‐GC‐MS and TGA‐FT‐IR methods have been used to perform a comparative degradation study of polystyrene and a polystyrene–clay composite. An abnormally high yield of __α__‐methylstyrene has been detected for the composite. This and other differences in degradation pr

Effects of blanching and freezing on the
Effects of blanching and freezing on the structure of carrots cells and their implications for food processing
✍ Préstamo, Guadalupe; Fuster, Carmen; Risueño, M Carmen 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 581 KB

Blanching and freezing e †ects are focused on the microscopic structure, whether the softening of frozen vegetables (carrots) is related to changes in pectic substances or to Ðrmness. Under light and electron microscopy, in the frozen raw samples, some cells were disrupted, producing cavities. The c

Effect of sorbitol and residual moisture
Effect of sorbitol and residual moisture on the stability of lyophilized antibodies: Implications for the mechanism of protein stabilization in the solid state
✍ Liuquan (Lucy) Chang; Deanna Shepherd; Joanna Sun; Xiaolin (Charlie) Tang; Micha 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 174 KB 👁 1 views

## Purpose: To investigate the effect of plasticizers on the stability of protein formulations in the solid state and to apply these results to a study of mechanisms of protein stabilization by sugars in the solid sate. ## Methods: The igg1 antibody was formulated with either sucrose or trehalose